This duo has played partners in multiple films including American Hustle, Vice and The Fighter.
Whether he plays her dick of a boyfriend in Wedding Crashers or a celebrated military contracter looking for love in Aloha, this pair knows how to garner attention with their on-screen presence.
Whether their characters' romances are a subplot (Brokeback Mountain) or the main story (Love and Other Drugs), this adorable duo shines in tear-jerking flicks.
What range! In the film Serena, the gorgeous stars portrayed newlyweds based in the '30s, opposite to their modern-day serendipitous meeting in Silver Linings Playbook.
As if making the totally '80s totally adorable in The Wedding Singer wasn't enough, these goofball sweethearts gave us shiny, happy 50 First Dates. Mahalo!
Speed marked Oscar winner Sandy's leading-lady debut. She and Keanu reteamed 12 years later for the time-bending Lake House. As K would say, whoa.
After winning hearts in the weepy disaster flick Titanic, the awards-bait duo showed us what could have happened had both Rose and Jack survived the sinking ship in the tumultuous Revolutionary Road.
From fumbling romance (How to Lose a Guy in 10 Days) to finding treasure (Fool's Gold), Katie and Matty are like catalog models in love.
These two defined smitten in the sweet Before Sunrise and brought gravity to the same situation nine years later in Before Sunset.
From Pretty Woman to Runaway Bride, Roberts and Gere epitomize the romantic-comedy genre...and all its love-'em-or-hate-'em clichés.
America's then sweetheart and the everyman seemed to do best in rom-coms where they don't know they're in love with each other. Hence our pics of Sleepless in Seattle and You've Got Mail and not Joe vs. the Volcano.
See real-life romances in our Celeb Weddings We Can't Wait For gallery!