Offred, or June as she declares her given name as at the end of the first episode, is a Handmaid doing her best to survive. Her reason for living? Her daughter, Hannah, who was taken from her as the regime to Gilead came to power. She resides in Commander Waterford's house and is partnered with Ofglen—Handmaid's always travel in pairs.
Moira and Offred were best friends from college before everything went down. They protested the rise of Gilead together and reconnected at the Red Center, the Handmaid training center, but Offred lost contact with Moira after being assigned to a household. In the first episode Offred is told Moira has been sent to the Colony and died...but did she?
Luke is Offred's husband from the world before Gilead and father to their daughter Hannah. He's seen through flashbacks throughout the series.
A fellow handmaid Offred meets in the Red Center, she who loses an eye as a form of punishment and soon loses grasp on reality.
A founding father of Gilead, Commander Waterford is a powerful and high-ranking official. He surprised Offred with a secret meeting…to play Scrabble.
Serena Joy is wife of Commander Waterford and the head of the household staff, including Offred. As wife to the Commander she's an influential public figure, and fought for traditional values as well as the establishment of Gilead.
Ofglen is a fellow Handmaid and companion to Offred, but there's more than meets the eye under the hood. Offred originally writes Ofglen off as a pious rule-follower, but Ofglen revealed herself as a member of the resistance. She was taken away for having a relationship with a Martha.
Nick serves as a Guardian in Gilead and as Commander Waterford's driver. He and Offred form a bond, but she's unsure about trusting him and suspects he could be an Eye, a spy for the secret police.
Aunt Lydia, who bears a striking resemblance to Miss Trunchbull from Matilda, runs the training center for the Handmaids and indoctrinates them into the Gilead system. She trains them, often through violence, for their role as sexual servants to the Commanders.